The Stockyards neighborhood is named after the livestock yards located in the area in the earlier part of this century. Owned by the Cleveland Union Stockyards Company, the yards themselves (pens, troughs, brick walkways and bidding areas) comprised over sixty acres of land and in 1920 were the nation's seventh largest livestock yards. The Cleveland Provision Company, the city's leading meat packer, moved to the stockyards in the 1890's with the arrival of mechanical refrigeration.

Dubbed the Hotel de la Hoff', the stockyards grew and prospered until the post-World War II era, when the livestock industry began to move westward and trucking replaced rail transportation. The yards finally closed in 1968, after having reduced to thirty-five acres. A large part of the area was redeveloped as a shopping center.

Stockyards was originally part of Brooklyn Township, absorbed by the City of Cleveland at the turn of the century through annexation. The Irish and the Germans were the first groups of immigrants to live in the area, followed later by Czechs, Slovaks, Poles and Italians. All peoples were drawn to the area because of the industries which had developed along the rail lines that ran through Walworth Run valley, notably the Pilsner Brewing Company and the Cleveland Union Stockyards Company.

The construction of I-71 and I-90 separated and isolated the Stockyards from the neighboring Detroit-Shoreway and Old Brooklyn areas. Recently, along with other neighborhoods on the near-west side, the Stockyards has become home to a portion of Cleveland's Hispanic community.