| 1863 | Free home delivery of mail - Joseph Briggs
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| 1879 | Electric lighting of public streets - Charles F. Brush
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| 1880 | Standardized formula paints - Sherwin Williams Co.
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| 1890 | Indoor shopping center (The Arcade)
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| 1896 | X-Ray photograph in the U.S. - Dudley Wick (his hand)
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| 1898 | Automobile sale in the U.S. - Alexander Winton
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| 1899 | Wound-rubber core golf ball - Haskell Coburn
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| 1900 | Automobile Club
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| 1901 | Automobile steering wheel - Alexander Winton
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| 1905 | Blood transfusion - Dr. George W. Crile, Sr.
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| 1910 | Automobile shock absorbers - C. H. Foster
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| 1914 | Electric traffic signal - Euclid Ave. & East 105th
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| 1915 | Submachine gun
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| 1916 | Gas mask demonstrated at Cleveland Waterworks Explosion - Garrett A. Morgan
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| 1920 | Unassisted triple play in a World Series Baseball Game
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| 1927 | Municipal airport (Cleveland Hopkins International) and air traffic control tower
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| 1928 | Frosted light bulbs - M. Pipkin
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| 1929 | Airplane automatic pilot - (tested)
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| 1940 | Health Museum
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| 1951 | Rock and Roll Music (public recognition and coinage of the term) - Alan Freed
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| 1952 | Successful siamese twin separation
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| 1967 | Black mayor of a major U.S. city - Carl B. Stokes, elected. Coronary artery bypass - Dr. Favaloro - Cleveland Clinic
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| 1968 | Rapid transit rail service from airport to downtown
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